Tetrahydrofuran → 2-Bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
Reaction equation
[Br:20][c:21]1[cH:22][c:23]([C:24](=[O:25])[OH:26])[c:27]([F:30])[cH:28][n:29]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:1][Si:2]([CH3:3])([CH3:4])[N-:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[CH3:36][CH2:37][O:38][C:39]([CH3:40])=[O:41].[F:11][c:12]1[c:13]([NH2:14])[cH:15][cH:16][c:17]([I:19])[cH:18]1.[Li+:10]>>[F:11][c:12]1[c:13]([NH:14][c:27]2[c:23]([C:24](=[O:25])[OH:26])[cH:22][c:21]([Br:20])[n:29][cH:28]2)[cH:15][cH:16][c:17]([I:19])[cH:18]1Participants
7
Sources & evidence
- ORD record
- ord-41d95374375541b4ac823f2bfcbc28ee
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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