Iodoethane → Tert-butyl 5-[2-(dibenzylamino)-3-(3,5-difluorophenyl)-1-phenylmethoxypropyl]-3-ethyl-2-oxomorpholine-4-carboxylate

HRID 1127198Notes

Reaction equation

HRID 1127198 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][C:20](=[O:58])[O:21][CH2:22][CH:23]1[CH:24]([CH:25]([CH2:26][c:27]1[cH:28][c:29]([F:34])[cH:30][c:31]([F:33])[cH:32]1)[N:35]([CH2:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[CH2:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)[O:50][CH2:51][c:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1.[CH3:1][Si:2]([CH3:3])([CH3:4])[N-:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[I:59][CH2:60][CH3:61].[Li+:10].[O:62]1[CH2:63][CH2:64][CH2:65][CH2:66]1>>[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH:19]([CH2:60][CH3:61])[C:20](=[O:58])[O:21][CH2:22][CH:23]1[CH:24]([CH:25]([CH2:26][c:27]1[cH:28][c:29]([F:34])[cH:30][c:31]([F:33])[cH:32]1)[N:35]([CH2:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[CH2:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)[O:50][CH2:51][c:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1

Participants

6

Reactant 5

HCID 6340IodoethaneHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 178452482HCID 178452482, compound

Product 1

HCID 77514020Tert-butyl 5-[2-(dibenzylamino)-3-(3,5-difluorophenyl)-1-phenylmethoxypropyl]-3-ethyl-2-oxomorpholine-4-carboxylate

Sources & evidence

ORD record
ord-cbd4d344d3824d6a8a8a450f906ce235
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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