Hydrochloric Acid → (2,5-Dichloro-4-pyridyl)(2,6-difluorophenyl)methanol

HRID 1129170Notes

Reaction equation

HRID 1129170 reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:32][CH2:33][O:34][C:35](=[O:36])[CH3:37].[CH3:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].[CH:6]([NH:7][CH:8]([CH3:9])[CH3:10])([CH3:11])[CH3:12].[Cl:13][c:14]1[n:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]1.[ClH:31].[F:21][c:22]1[c:23]([CH:24]=[O:25])[c:26]([F:30])[cH:27][cH:28][cH:29]1.[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1>>[Cl:13][c:14]1[n:15][cH:16][c:17]([Cl:20])[c:18]([CH:24]([c:23]2[c:22]([F:21])[cH:29][cH:28][cH:27][c:26]2[F:30])[OH:25])[cH:19]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 276852,5-DichloropyridineHCID 1362842,6-DifluorobenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 23114780(2,5-Dichloro-4-pyridyl)(2,6-difluorophenyl)methanol

Sources & evidence

ORD record
ord-59347bc8b8af473fba0596ab6dc43df8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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