Hydrochloric Acid → tert-Butyl 4-(2-isopropylthiazole-5-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

HRID 1130181Notes

Reaction equation

HRID 1130181 reaction equation
[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[CH:27]([CH3:28])([CH3:29])[c:30]1[s:31][c:32]([C:35](=[O:36])[OH:37])[cH:33][n:34]1.[ClH:1].[O:2]1[CH2:3][CH2:4][NH:5][CH2:6][C:7]12[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2.[O:62]=[CH:63][N:64]([CH3:65])[CH3:66].[P-:38]([F:39])([F:40])([F:41])([F:42])([F:43])[F:44].[n:45]1([O:46][C:47]([N:48]([CH3:49])[CH3:50])=[N+:51]([CH3:52])[CH3:53])[c:54]2[n:55][cH:56][cH:57][cH:58][c:59]2[n:60][n:61]1>>[O:2]1[CH2:3][CH2:4][N:5]([C:35]([c:32]2[s:31][c:30]([CH:27]([CH3:28])[CH3:29])[n:34][cH:33]2)=[O:36])[CH2:6][C:7]12[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 197863422-(Propan-2-yl)-1,3-thiazole-5-carboxylic acidHCID 53302318tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 57989386tert-Butyl 4-(2-isopropylthiazole-5-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Sources & evidence

ORD record
ord-0f07b91eaa634b6cbed486a76abc2e8a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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