Acetate → 4-(4-Tert-butoxycarbonylamino-naphthalen-1-yloxy)-pyrimidine-2-carboxylic acid methyl ester

HRID 1131922Notes

Reaction equation

HRID 1131922 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[cH:9][cH:10][c:11]([O:18][c:19]2[n:20][c:21]([I:25])[n:22][cH:23][cH:24]2)[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]12)=[O:26].[CH3:27][OH:28].[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[CH3:41][CH2:42][O:43][C:44]([CH3:45])=[O:46].[O-:48][C:49]([CH3:50])=[O:51].[O-:52][C:53]([CH3:54])=[O:55].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40].[Pd+2:47]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[cH:9][cH:10][c:11]([O:18][c:19]2[n:20][c:21]([C:37]([O:28][CH3:27])=[O:36])[n:22][cH:23][cH:24]2)[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]12)=[O:26]

Participants

8

Reactant 7

HCID 175Acetate2×HCID 887MethanolHCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 20756578[4-(2-Iodo-pyrimidin-4-yloxy)-naphthalen-1-yl]-carbamic acid tert-butyl ester

Product 1

HCID 697355324-(4-Tert-butoxycarbonylamino-naphthalen-1-yloxy)-pyrimidine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-7b88da65ee2b4ae5ac70a03bcef659b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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