Tetrahydrofuran → Methyl 2-[4-[3-(4-fluorophenyl)-3-[4-(3-pyrazol-1-ylprop-1-ynyl)phenyl]prop-2-enoxy]-2-methylphenoxy]acetate
Reaction equation
[CH2:32]([C:33]#[CH:34])[n:35]1[n:36][cH:37][cH:38][cH:39]1.[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[Cu:52][I:53].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[CH:9][CH2:10][O:11][c:12]2[cH:13][c:14]([CH3:24])[c:15]([O:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23]2)[c:25]2[cH:26][cH:27][c:28]([I:31])[cH:29][cH:30]2)[cH:6][cH:7]1.[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1.[cH:54]1[cH:55][cH:56][c:57]([P:58]([Pd:59]([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)([P:79]([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)([c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)[c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)[P:98]([c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)([c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)([c:117]2[cH:118][cH:119][cH:120][cH:121][cH:122]2)[c:123]2[cH:124][cH:125][cH:126][cH:127][cH:128]2)[cH:129][cH:130]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[CH:9][CH2:10][O:11][c:12]2[cH:13][c:14]([CH3:24])[c:15]([O:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23]2)[c:25]2[cH:26][cH:27][c:28]([C:34]#[C:33][CH2:32][n:35]3[n:36][cH:37][cH:38][cH:39]3)[cH:29][cH:30]2)[cH:6][cH:7]1Participants
7
Reactant 6
HCID 8028Tetrahydrofuran
HCID 8471Triethylamine
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 117685231-(prop-2-yn-1-yl)-1H-pyrazole
HCID 90986677Methyl 2-[4-[3-(4-fluorophenyl)-3-(4-iodophenyl)prop-2-enoxy]-2-methylphenoxy]acetate
HCID 178420554HCID 178420554, compoundProduct 1
Sources & evidence
- ORD record
- ord-6d5bf2aa2b4e427a857d70eb290eb93b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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