Hydrochloric Acid → N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-oxopiperidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

HRID 1133542Notes

Reaction equation

HRID 1133542 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:14](=[O:15])[NH:16][CH2:17][c:18]2[c:19](=[O:26])[nH:20][c:21]([CH3:25])[cH:22][c:23]2[CH3:24])[c:5]2[c:6]([n:7]1)[n:8]([CH:11]([CH3:12])[CH3:13])[n:9][cH:10]2.[CH3:47][OH:48].[Cl:49][CH2:50][Cl:51].[ClH:40].[K+:27].[K+:28].[NH:33]1[CH2:34][CH2:35][C:36](=[O:39])[CH2:37][CH2:38]1.[O-:29][C:30]([O-:31])=[O:32].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[OH2:41]>>[c:2]1([N:33]2[CH2:34][CH2:35][C:36](=[O:39])[CH2:37][CH2:38]2)[cH:3][c:4]([C:14](=[O:15])[NH:16][CH2:17][c:18]2[c:19](=[O:26])[nH:20][c:21]([CH3:25])[cH:22][c:23]2[CH3:24])[c:5]2[c:6]([n:7]1)[n:8]([CH:11]([CH3:12])[CH3:13])[n:9][cH:10]2

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 887MethanolHCID 962WaterHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 337214-PiperidoneHCID 867034096-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Product 1

HCID 68295699N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-oxopiperidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Sources & evidence

ORD record
ord-4fa3ff726ad042de94b27e3e593c1a00
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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