Tetrahydrofuran → t-Butyl N-[4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-3-methylbutyl]-N-methylsulfonylcarbamate

HRID 1134754Notes

Reaction equation

HRID 1134754 reaction equation
[CH3:25][S:26](=[O:27])(=[O:28])[NH:29][C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36].[CH3:61][CH2:62][O:63][C:64](=[O:65])[CH3:66].[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH:12]([CH2:13][CH2:14][OH:15])[CH3:16])[c:17]2[c:18]([F:24])[cH:19][cH:20][c:21]([F:23])[cH:22]2)[cH:6][cH:7]1.[O:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1.[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH:12]([CH2:13][CH2:14][N:29]([S:26]([CH3:25])(=[O:27])=[O:28])[C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36])[CH3:16])[c:17]2[c:18]([F:24])[cH:19][cH:20][c:21]([F:23])[cH:22]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 11776TriphenylphosphineHCID 10081367tert-Butyl methylsulfonylcarbamateHCID 230288584-(4-Chlorophenylsulfonyl)-4-(2,5-difluorophenyl)-3-methyl-1-butanol

Product 1

HCID 59750918t-Butyl N-[4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-3-methylbutyl]-N-methylsulfonylcarbamate

Sources & evidence

ORD record
ord-1657ba81d7d74708b87a39166b0bf590
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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