Tetrahydrofuran → 3-(4-Fluorophenyl)-5-[2-(2-chlorophenyl)propionylamino]-4-[4-pyrimidinyl]isoxazole
Reaction equation
[C:13]([n:14]1[cH:15][cH:16][n:17][cH:18]1)([n:19]1[cH:20][cH:21][n:22][cH:23]1)=[O:24].[CH2:25]1[CH2:26][CH2:27][C:28]2=[N:33][CH2:32][CH2:31][CH2:30][N:29]2[CH2:34][CH2:35]1.[CH2:55]1[O:56][CH2:57][CH2:58][CH2:59]1.[Cl:1][c:2]1[c:3]([CH:8]([C:9](=[O:10])[OH:11])[CH3:12])[cH:4][cH:5][cH:6][cH:7]1.[NH2:36][c:37]1[c:38](-[c:49]2[n:50][cH:51][n:52][cH:53][cH:54]2)[c:39](-[c:42]2[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]2)[n:40][o:41]1>>[Cl:1][c:2]1[c:3]([CH:8]([C:9](=[O:11])[NH:36][c:37]2[c:38](-[c:49]3[n:50][cH:51][n:52][cH:53][cH:54]3)[c:39](-[c:42]3[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]3)[n:40][o:41]2)[CH3:12])[cH:4][cH:5][cH:6][cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-13d966de17074c7296fd462d3a65c0ec
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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