Dichloromethane → tert-butyl (3SR,4RS,5RS)-4-[4-(2-benzyloxy-ethoxymethyl)-phenyl]-3-hydroxymethyl-5-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate
Reaction equation
[CH2:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[O:19][CH2:20][CH2:21][O:22][CH2:23][c:24]1[cH:25][cH:26][c:27]([CH:30]2[CH:31]([O:64][CH2:65][c:66]3[cH:67][c:68]4[cH:69][cH:70][cH:71][cH:72][c:73]4[cH:74][cH:75]3)[CH2:32][N:33]([C:57](=[O:58])[O:59][C:60]([CH3:61])([CH3:62])[CH3:63])[CH2:34][CH:35]2[CH2:36][O:37][C:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:28][cH:29]1.[CH2:1]([O:2][CH2:3][CH2:4][I:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[CH2:96]([Cl:97])[Cl:98].[F:83][C:84]([F:85])([F:86])[C:87]([O:88][C:89](=[O:90])[C:91]([F:92])([F:93])[F:94])=[O:95].[OH:76][C:77]([C:78]([F:79])([F:80])[F:81])=[O:82]>>[CH2:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[O:19][CH2:20][CH2:21][O:22][CH2:23][c:24]1[cH:25][cH:26][c:27]([CH:30]2[CH:31]([O:64][CH2:65][c:66]3[cH:67][c:68]4[cH:69][cH:70][cH:71][cH:72][c:73]4[cH:74][cH:75]3)[CH2:32][N:33]([C:57](=[O:58])[O:59][C:60]([CH3:61])([CH3:62])[CH3:63])[CH2:34][CH:35]2[CH2:36][OH:37])[cH:28][cH:29]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-8b95f32a594d42cfb05dd40f9123de81
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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