Chloride → Methyl 5-(2,2-difluoroethoxy)pyrazine-2-carboxylate

HRID 1138712Notes

Reaction equation

HRID 1138712 reaction equation
[Br:7][CH2:8][CH:9]([F:10])[F:11].[C:1](=[O:2])([O-:3])[O-:4].[CH3:30][CH2:31][O:32][C:33](=[O:34])[CH3:35].[Cl-:24].[Cs+:5].[Cs+:6].[Na+:23].[O:25]=[CH:26][N:27]([CH3:28])[CH3:29].[OH:12][c:13]1[n:14][cH:15][c:16]([C:19](=[O:20])[O:21][CH3:22])[n:17][cH:18]1>>[CH2:8]([CH:9]([F:10])[F:11])[O:12][c:13]1[n:14][cH:15][c:16]([C:19](=[O:20])[O:21][CH3:22])[n:17][cH:18]1

Participants

9

Reactant 8

HCID 312ChlorideHCID 923Sodium ionHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 1361862-Bromo-1,1-difluoroethaneHCID 178498852HCID 178498852, compound

Product 1

HCID 57827325Methyl 5-(2,2-difluoroethoxy)pyrazine-2-carboxylate

Sources & evidence

ORD record
ord-397d0ab8703b40dca144a9caaa679389
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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