Ethanol → 4'-Fluoro(1,1'-biphenyl)-2-amine

HRID 1138794Notes

Reaction equation

HRID 1138794 reaction equation
[BH:34]([OH:35])[OH:36].[Br:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][cH:7][cH:8]1.[CH3:37][CH2:38][OH:39].[CH3:40][CH2:41][O:42][C:43](=[O:44])[CH3:45].[CH3:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17].[Na+:18].[Na+:19].[O-:20][C:21](=[O:22])[O-:23].[OH:24][B:25]([OH:26])[c:27]1[cH:28][cH:29][c:30]([F:31])[cH:32][cH:33]1>>[c:2]1(-[c:27]2[cH:28][cH:29][c:30]([F:31])[cH:32][cH:33]2)[c:3]([NH2:4])[cH:5][cH:6][cH:7][cH:8]1

Participants

9

Reactant 8

HCID 702EthanolHCID 923Sodium ion2×HCID 8150DiglymeHCID 8857Ethyl AcetateHCID 119922-BromoanilineHCID 19660Carbonate IonHCID 61668Boronic AcidHCID 2856454-Fluorophenylboronic acid

Product 1

HCID 27589754'-Fluoro(1,1'-biphenyl)-2-amine

Sources & evidence

ORD record
ord-9905d173532041eba2d3b19c9f2741d3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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