Dichloromethane → N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-4-(4-benzyloxy-3-methoxyphenyl)-1,3-butadiene-1-carboxamide

HRID 1138796Notes

Reaction equation

HRID 1138796 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([O:22][CH3:23])[cH:11][c:12]([CH:15]=[CH:16][CH:17]=[CH:18][C:19](=[O:20])[OH:21])[cH:13][cH:14]1.[CH2:62]([Cl:63])[Cl:64].[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[CH3:40][N:41]([CH2:42][CH2:43][NH:44][CH:45]1[CH2:46][CH2:47][CH:48]([CH3:51])[CH2:49][CH2:50]1)[CH3:52].[CH3:53][N:54]([CH3:55])[c:56]1[cH:57][cH:58][n:59][cH:60][cH:61]1.[P:24]([Cl:25])([O:26][CH2:27][CH3:28])([O:29][CH2:30][CH3:31])=[O:32]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([O:22][CH3:23])[cH:11][c:12]([CH:15]=[CH:16][CH:17]=[CH:18][C:19](=[O:21])[N:44]([CH2:43][CH2:42][N:41]([CH3:40])[CH3:52])[CH:45]2[CH2:46][CH2:47][CH:48]([CH3:51])[CH2:49][CH2:50]2)[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 13139Diethyl chlorophosphateHCID 142844-(Dimethylamino)pyridineHCID 870794N-(2-dimethylaminoethyl)-cis-4-methylcyclohexylamineHCID 542250435-[4-(Benzyloxy)-3-methoxyphenyl]penta-2,4-dienoic acid

Product 1

HCID 53772368N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-4-(4-benzyloxy-3-methoxyphenyl)-1,3-butadiene-1-carboxamide

Sources & evidence

ORD record
ord-6f613757b20d4532a8a56036e068bd05
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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