Hydrochloric Acid → 9-benzyloxy-7-bromo-2-(3-chlorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

HRID 1140540Notes

Reaction equation

HRID 1140540 reaction equation
[CH3:40][S:41](=[O:42])(=[O:43])[Cl:44].[CH:31]([N:32]([CH2:33][CH3:34])[CH:35]([CH3:36])[CH3:37])([CH3:38])[CH3:39].[Cl:1][c:2]1[cH:3][c:4]([CH2:5][NH:6][C:7](=[O:8])[c:9]2[n:10]([CH2:25][CH2:26][OH:27])[cH:11][c:12]([Br:24])[c:13](=[O:23])[c:14]2[O:15][CH2:16][c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:28][cH:29][cH:30]1.[ClH:45].[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]2[C:7](=[O:8])[c:9]3[n:10]([cH:11][c:12]([Br:24])[c:13](=[O:23])[c:14]3[O:15][CH2:16][c:17]3[cH:18][cH:19][cH:20][cH:21][cH:22]3)[CH2:25][CH2:26]2)[cH:28][cH:29][cH:30]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 588591603-Benzyloxy-5-bromo-1-(2-hydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 3-chlorobenzylamide

Product 1

HCID 230776699-benzyloxy-7-bromo-2-(3-chlorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Sources & evidence

ORD record
ord-f103b993a03b46a9a18e4ae690ee7801
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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