Tetrahydrofuran → tert-Butyl 3-(7-amino-2H-benzo[b][1,4]thiazin-4(3H)-yl)pyrrolidine-1-carboxylate

HRID 1142469Notes

Reaction equation

HRID 1142469 reaction equation
[Br:14][c:15]1[cH:16][cH:17][c:18]2[c:19]([cH:36]1)[S:20][CH2:21][CH2:22][N:23]2[CH:24]1[CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1.[C:1]([P:2]([C:3]([CH3:4])([CH3:5])[CH3:6])[C:7]([CH3:8])([CH3:9])[CH3:10])([CH3:11])([CH3:12])[CH3:13].[CH2:38]([N+:42]([CH2:39][CH2:40][CH2:41][CH3:43])([CH2:44][CH2:45][CH2:46][CH3:47])[CH2:48][CH2:49][CH2:50][CH3:51])[CH2:52][CH2:53][CH3:54].[CH2:55]1[O:56][CH2:57][CH2:58][CH2:59]1.[CH3:61][Si:62]([N-:63][Si:64]([CH3:65])([CH3:66])[CH3:67])([CH3:68])[CH3:69].[F-:37].[Li+:60].[O:108]=[C:109]([CH:110]=[CH:111][c:112]1[cH:113][cH:114][cH:115][cH:116][cH:117]1)[CH:118]=[CH:119][c:120]1[cH:121][cH:122][cH:123][cH:124][cH:125]1.[O:72]=[C:73]([CH:74]=[CH:75][c:76]1[cH:77][cH:78][cH:79][cH:80][cH:81]1)[CH:82]=[CH:83][c:84]1[cH:85][cH:86][cH:87][cH:88][cH:89]1.[O:90]=[C:91]([CH:92]=[CH:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1)[CH:100]=[CH:101][c:102]1[cH:103][cH:104][cH:105][cH:106][cH:107]1.[Pd:70].[Pd:71]>>[c:15]1([NH2:42])[cH:16][cH:17][c:18]2[c:19]([cH:36]1)[S:20][CH2:21][CH2:22][N:23]2[CH:24]1[CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1

Participants

10

Reactant 9

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 23938Palladium2×HCID 28179Fluoride IonHCID 28486Lithium ionHCID 83681Tris(1,1-dimethylethyl)phosphineHCID 95417Dibenzylidene acetone3×HCID 3280088Npc316347HCID 59144137tert-Butyl 3-(7-bromo-2H-benzo[b][1,4]thiazin-4(3H)-yl)pyrrolidine-1-carboxylate

Product 1

HCID 59144157tert-Butyl 3-(7-amino-2H-benzo[b][1,4]thiazin-4(3H)-yl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-2f7b732917264dfdb4d821947af80b11
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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