Ammonium → tert-Butyl 2-(4-Formylphenyl)-2-hydroxyethyl(methyl)carbamate

HRID 1144473Notes

Reaction equation

HRID 1144473 reaction equation
[Br-:28].[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][N:10]([C:11]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17])[CH3:18])[OH:19])[cH:6][cH:7]1.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:20][N:21]([CH3:22])[CH2:23][CH2:24][N:25]([CH3:26])[CH3:27].[CH3:29][Mg+:30].[CH3:31][CH2:32][CH2:33][CH2:34][Li:35].[CH3:48][CH2:49][CH2:50][CH2:51][CH2:52][CH3:53].[Cl-:41].[NH4+:42].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[c:2]1([CH:37]=[O:36])[cH:3][cH:4][c:5]([CH:8]([CH2:9][N:10]([C:11]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17])[CH3:18])[OH:19])[cH:6][cH:7]1

Participants

11

Reactant 10

HCID 223AmmoniumHCID 259Bromide ionHCID 312ChlorideHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 8058HexaneHCID 22574334tert-butyl N-[2-(4-bromophenyl)-2-hydroxyethyl]-N-methylcarbamateHCID 178418339ButyllithiumHCID 178477777HCID 178477777, compound

Product 1

HCID 22574298tert-Butyl 2-(4-Formylphenyl)-2-hydroxyethyl(methyl)carbamate

Sources & evidence

ORD record
ord-9e1fece276e54d889cad98ef2b6bfd02
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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