Hydrochloric Acid → 6-chloro-4'-[5-chloro-2-(3-methanesulfonylamino-2,2-dimethyl-3-oxo-propoxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 1145398Notes

Reaction equation

HRID 1145398 reaction equation
[C:41]([n:42]1[cH:43][cH:44][n:45][cH:46]1)([n:47]1[cH:48][cH:49][n:50][cH:51]1)=[O:52].[CH3:53][S:54](=[O:55])(=[O:56])[NH2:57].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:33]2[c:34]([CH3:40])[cH:35][cH:36][c:37]([F:39])[cH:38]2)[NH:13][C:14](=[O:32])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][CH2:25][C:26]([CH3:27])([CH3:28])[C:29](=[O:30])[OH:31])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[ClH:60].[H-:59].[Na+:58].[O:61]=[CH:62][N:63]([CH3:64])[CH3:65].[OH2:66]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:33]2[c:34]([CH3:40])[cH:35][cH:36][c:37]([F:39])[cH:38]2)[NH:13][C:14](=[O:32])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][CH2:25][C:26]([CH3:27])([CH3:28])[C:29](=[O:30])[NH:57][S:54]([CH3:53])(=[O:55])=[O:56])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 682631,1'-CarbonyldiimidazoleHCID 72879MethanesulfonamideHCID 166653HydrideHCID 765678616-chloro-4'-[5-chloro-2-(2-hydroxycarbonyl-2-methyl-propoxy)-phenyl]-2'-(5-fluoro-2-methylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Product 1

HCID 866320956-chloro-4'-[5-chloro-2-(3-methanesulfonylamino-2,2-dimethyl-3-oxo-propoxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-f8ea30f870b34ab7ab11a4b259db4a46
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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