1,2-Dichloroethane → 4-hydroxy-2,2-dimethyl-4-[5-[3-methyl-5-[[4-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-1,3-thiazol-2-yl]-N-[3-(2-oxopyrrolidin-1-yl)propyl]cyclohexane-1-carboxamide
Reaction equation
[CH2:46]([Cl:47])[CH2:48][Cl:49].[CH3:60][CH2:61][N:62]([CH2:63][CH3:64])[CH2:65][CH3:66].[CH3:67][N:68]([CH3:69])[CH:70]=[O:71].[NH2:36][CH2:37][CH2:38][CH2:39][N:40]1[C:41](=[O:45])[CH2:42][CH2:43][CH2:44]1.[OH:1][C:2]1([c:13]2[s:14][c:15](-[c:18]3[cH:19][c:20]([CH3:35])[cH:21][c:22]([NH:24][c:25]4[n:26][cH:27][cH:28][c:29]([C:31]([F:32])([F:33])[F:34])[n:30]4)[cH:23]3)[cH:16][n:17]2)[CH2:3][C:4]([CH3:11])([CH3:12])[CH:5]([C:8](=[O:9])[OH:10])[CH2:6][CH2:7]1.[OH:50][n:51]1[c:52]2[c:53]([cH:54][cH:55][cH:56][cH:57]2)[n:58][n:59]1>>[OH:1][C:2]1([c:13]2[s:14][c:15](-[c:18]3[cH:19][c:20]([CH3:35])[cH:21][c:22]([NH:24][c:25]4[n:26][cH:27][cH:28][c:29]([C:31]([F:32])([F:33])[F:34])[n:30]4)[cH:23]3)[cH:16][n:17]2)[CH2:3][C:4]([CH3:11])([CH3:12])[CH:5]([C:8](=[O:10])[NH:36][CH2:37][CH2:38][CH2:39][N:40]2[C:41](=[O:45])[CH2:42][CH2:43][CH2:44]2)[CH2:6][CH2:7]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-681f14408a604f86a0437472c4caae16
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
Loading…