Tetrahydrofuran → 5-Bromo-3-(3-trimethylsilanyl-prop-1-ynyl)-pyrazin-2-ylamine

HRID 1147871Notes

Reaction equation

HRID 1147871 reaction equation
[Br:1][c:2]1[c:3]([NH2:9])[n:4][cH:5][c:6]([Br:8])[n:7]1.[CH2:17]1[O:18][CH2:19][CH2:20][CH2:21]1.[CH3:10][Si:11]([CH2:12][C:13]#[CH:14])([CH3:15])[CH3:16].[CH3:22][CH2:23][O:24][C:25]([CH3:26])=[O:27].[Cu:28][I:29]>>[c:2]1([C:14]#[C:13][CH2:12][Si:11]([CH3:10])([CH3:15])[CH3:16])[c:3]([NH2:9])[n:4][cH:5][c:6]([Br:8])[n:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 83378Trimethyl-2-propynylsilaneHCID 6200042-Amino-3,5-dibromopyrazine

Product 1

HCID 866423045-Bromo-3-(3-trimethylsilanyl-prop-1-ynyl)-pyrazin-2-ylamine

Sources & evidence

ORD record
ord-2ff9449e00d647939375352763d58d19
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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