Tetrahydrofuran → 2-[1-(2-chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(3-methyl-1,2,4-thiadiazol-5-yl)propanamide

HRID 1148772Notes

Reaction equation

HRID 1148772 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:1][Si:2]([N-:3][Si:4]([CH3:5])([CH3:6])[CH3:7])([CH3:8])[CH3:9].[CH3:47][CH2:48][O:49][C:50]([CH3:51])=[O:52].[Cl:25][c:26]1[c:27]2[c:28]([n:29][cH:30][n:31]1)[n:32](-[c:35]1[c:36]([Cl:41])[cH:37][cH:38][cH:39][cH:40]1)[n:33][cH:34]2.[Li+:10].[OH:11][CH:12]([C:13](=[O:14])[NH:15][c:16]1[n:17][c:18]([CH3:21])[n:19][s:20]1)[CH2:22][O:23][CH3:24]>>[O:11]([CH:12]([C:13](=[O:14])[NH:15][c:16]1[n:17][c:18]([CH3:21])[n:19][s:20]1)[CH2:22][O:23][CH3:24])[c:26]1[c:27]2[c:28]([n:29][cH:30][n:31]1)[n:32](-[c:35]1[c:36]([Cl:41])[cH:37][cH:38][cH:39][cH:40]1)[n:33][cH:34]2

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 3280088Npc316347HCID 112655704-Chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-D]pyrimidineHCID 668132722-hydroxy-3-methoxy-N-(3-methyl-1,2,4-thiadiazol-5-yl)propanamide

Product 1

HCID 765503422-[1-(2-chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(3-methyl-1,2,4-thiadiazol-5-yl)propanamide

Sources & evidence

ORD record
ord-13e6deff8d6441cb8c7a57507b8b08e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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