Hydrochloric Acid → 4-(4-Fluoro-2-(tetrahydro-2H-pyran-4-yloxy)phenylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Reaction equation
[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[ClH:32].[F:4][c:5]1[cH:6][c:7]([O:25][CH:26]2[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[c:8]([NH:11][c:12]2[c:13]3[c:14]([n:15][cH:16][n:17]2)[s:18][c:19]([C:21](=[O:22])[O:23][CH3:24])[cH:20]3)[cH:9][cH:10]1.[Li+:3].[OH-:2].[OH2:1].[OH2:38]>>[F:4][c:5]1[cH:6][c:7]([O:25][CH:26]2[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[c:8]([NH:11][c:12]2[c:13]3[c:14]([n:15][cH:16][n:17]2)[s:18][c:19]([C:21](=[O:22])[OH:23])[cH:20]3)[cH:9][cH:10]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-109fd84567934a648e70085e2e9885da
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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