Methanol → 2,2-difluoro-N'-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-(3-methoxyquinolin-6-yl)acetohydrazide

HRID 1149862Notes

Reaction equation

HRID 1149862 reaction equation
[CH3:70][N:71]([CH3:72])[c:73]1[cH:74][cH:75][n:76][cH:77][cH:78]1.[CH3:82][OH:83].[CH3:84][CH2:85][N:86]([CH2:87][CH3:88])[CH2:89][CH3:90].[Cl:79][CH2:80][Cl:81].[F:1][C:2]([F:3])([c:4]1[cH:5][c:6]2[c:7]([cH:8][cH:9]1)[n:10][cH:11][c:12]([O:13][CH3:14])[cH:15]2)[C:16]([NH:17][NH:18][c:19]1[cH:20][c:21](-[c:22]2[cH:23][n:24][n:25]([CH3:26])[cH:27]2)[cH:28][cH:29][c:30]1[F:31])=[O:32].[F:33][C:34]([C:35](=[O:36])[OH:37])([c:38]1[cH:39][c:40]2[cH:41][c:42]([O:48][CH3:49])[cH:43][n:44][c:45]2[cH:46][cH:47]1)[F:50].[F:55][c:56]1[c:57]([NH:68][NH2:69])[n:58][cH:59][c:60](-[c:62]2[cH:63][n:64][n:65]([CH3:67])[cH:66]2)[cH:61]1.[O:91]=[CH:92][N:93]([CH3:94])[CH3:95].[S:51]([Cl:52])([Cl:53])=[O:54]>>[F:33][C:34]([C:35](=[O:37])[NH:69][NH:68][c:57]1[c:56]([F:55])[cH:61][c:60](-[c:62]2[cH:63][n:64][n:65]([CH3:67])[cH:66]2)[cH:59][n:58]1)([c:38]1[cH:39][c:40]2[cH:41][c:42]([O:48][CH3:49])[cH:43][n:44][c:45]2[cH:46][cH:47]1)[F:50]

Participants

10

Reactant 9

HCID 887MethanolHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 142844-(Dimethylamino)pyridineHCID 24386Thionyl ChlorideHCID 576912392,2-Difluoro-2-(3-methoxyquinolin-6-yl)acetic acidHCID 675032383-fluoro-2-hydrazinyl-5-(1-methyl-1H-pyrazol-4-yl)pyridineHCID 675037092,2-difluoro-N'-(2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-(3-methoxyquinolin-6-yl)acetohydrazide

Product 1

HCID 576913272,2-difluoro-N'-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-(3-methoxyquinolin-6-yl)acetohydrazide

Sources & evidence

ORD record
ord-a7039bc564174be0865c1d63d1bdf5c3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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