反应详情

温度

50 °C

A solution of 3-{[4-(3-Iodo-propoxy)-phenylamino]-methylene}-1,3-dihydro-indol-2-one (66 mg, 0.157 mmol) in 1 mL THF is treated with 1-methylpiperazine (37.2 μL, 2.2 equiv.) and the resulting reaction mixture is heated at 50° C. for 4 h. The reaction mixture is cooled to room temperature and concentrated under reduced pressure. The residue is partitioned between EtOAc and H2O. The organic layer is collected and washed with saturated aqueous NaHCO3, brine, and dried over anhydrous Na2SO4. The yellow solid residue obtained upon evaporation is broken up in 1:9 EtOAc:hexane and collected by filtration to give the named compound as a yellow solid.

1. customthe resulting reaction mixture
2. temperatureThe reaction mixture is cooled to room temperature
3. concentrationconcentrated under reduced pressure
4. customThe residue is partitioned between EtOAc and H2O
5. customThe organic layer is collected
6. washwashed with saturated aqueous NaHCO3, brine
7. dry with materialdried over anhydrous Na2SO4
8. customThe yellow solid residue obtained upon evaporation
9. filtrationhexane and collected by filtration