Dimethylformamide → 2-tert-Butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine

HRID 1151342Notes

Reaction equation

HRID 1151342 reaction equation
[Br:21][CH2:22][CH2:23][CH2:24][Cl:25].[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][c:7]([CH:17]2[CH2:18][CH2:19][CH2:20]2)[cH:8][c:9]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[n:10]1.[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:33][N:34]([CH3:35])[CH:36]=[O:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][c:7]([CH:17]2[CH2:18][CH2:19][CH2:20]2)[cH:8][c:9]([N:11]2[CH2:12][CH2:13][N:14]([CH2:22][CH2:23][CH2:24][Cl:25])[CH2:15][CH2:16]2)[n:10]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 80061-Bromo-3-chloropropaneHCID 8471TriethylamineHCID 666733902-tert-Butyl-4-cyclobutyl-6-(piperazin-1-yl)pyrimidine

Product 1

HCID 666731042-tert-Butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine

Sources & evidence

ORD record
ord-3dfb512db79c4b14bea045853ff72cbb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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