Dimethylformamide → N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-2-[4-[(2,3-dihydroxypropylamino)methyl]phenyl]acetamide

HRID 1152296Notes

Reaction equation

HRID 1152296 reaction equation
[Br:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([CH2:15][C:16](=[O:17])[NH:18][c:19]2[s:20][c:21]([S:24][CH2:25][c:26]3[o:27][c:28]([C:31]([CH3:32])([CH3:33])[CH3:34])[cH:29][n:30]3)[cH:22][n:23]2)[cH:13][cH:14]1.[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[CH3:40][CH2:41][O:42][C:43](=[O:44])[CH3:45].[NH2:1][CH2:2][CH:3]([CH2:4][OH:5])[OH:6]>>[NH:1]([CH2:2][CH:3]([CH2:4][OH:5])[OH:6])[CH2:8][c:9]1[cH:10][cH:11][c:12]([CH2:15][C:16](=[O:17])[NH:18][c:19]2[s:20][c:21]([S:24][CH2:25][c:26]3[o:27][c:28]([C:31]([CH3:32])([CH3:33])[CH3:34])[cH:29][n:30]3)[cH:22][n:23]2)[cH:13][cH:14]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 735613-Amino-1,2-propanediolHCID 111136012-[4-(bromomethyl)phenyl]-N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]acetamide

Product 1

HCID 9891769N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-2-[4-[(2,3-dihydroxypropylamino)methyl]phenyl]acetamide

Sources & evidence

ORD record
ord-014d0321a2b44794ba43580faa536a49
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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