Tetrahydrofuran → N-(6-methoxypyridin-3-yl)-3-(4-methyl-1,3,5-triazin-2-yl)-5-((4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-2-amine
Reaction equation
[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:2][Si:3]([N-:4][Si:5]([CH3:6])([CH3:7])[CH3:8])([CH3:9])[CH3:10].[F:11][c:12]1[n:13][cH:14][c:15]([CH2:25][N:26]2[CH2:27][CH2:28][N:29]([S:32](=[O:33])(=[O:34])[CH3:35])[CH2:30][CH2:31]2)[cH:16][c:17]1-[c:18]1[n:19][cH:20][n:21][c:22]([CH3:24])[n:23]1.[Li+:1].[NH2:36][c:37]1[cH:38][n:39][c:40]([O:43][CH3:44])[cH:41][cH:42]1>>[c:12]1([NH:36][c:37]2[cH:38][n:39][c:40]([O:43][CH3:44])[cH:41][cH:42]2)[n:13][cH:14][c:15]([CH2:25][N:26]2[CH2:27][CH2:28][N:29]([S:32](=[O:33])(=[O:34])[CH3:35])[CH2:30][CH2:31]2)[cH:16][c:17]1-[c:18]1[n:19][cH:20][n:21][c:22]([CH3:24])[n:23]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-216fdcca73e84846a739bdc27f407bd4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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