Triethylamine → HCID 20437026, compound

HRID 1153789Notes

Reaction equation

HRID 1153789 reaction equation
[OH:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[S:12][C:11]([S:13]([NH2:16])(=[O:15])=[O:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl[C:27]([O:29][CH2:30][CH:31]([CH3:33])[CH3:32])=[O:28]>CC(C)=O>[C:27](=[O:28])([O:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[S:12][C:11]([S:13](=[O:15])(=[O:14])[NH2:16])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1)[O:29][CH2:30][CH:31]([CH3:33])[CH3:32]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62365Isobutyl chloroformateHCID 13364601HCID 13364601, compound

Product 1

HCID 20437026HCID 20437026, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 5-(4-hydroxybenzoyl)thiophene-2-sulfonamide (0.00783 mole) in acetone (50 ml) at 0° C. is treated with triethylamine (0.00861 mole) followed by isobutyl chloroformate (0.00861 mole) dropwise, during 30 minutes at 0°-2° C.

Workup

  1. customduring 30 minutes
  2. customat 0°-2° C.

Sources & evidence

ORD record
ord-78af13bfa7244f1daef95b5aef4bfafa
Source dataset
uspto-grants-1984_12
Patent number
US04486444

Reaction notes

Loading…