Tetrahydrofuran → HCID 178442015, compound

HRID 1153812Notes

Reaction equation

HRID 1153812 reaction equation
Cl[CH:2]([CH2:27][CH2:28][CH3:29])[C:3]([NH:5][C:6]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][CH:9]=[CH:8][C:7]=1[C:16](=[O:26])[CH2:17][C:18]([NH:20][C:21]1[S:22][CH:23]=[CH:24][N:25]=1)=[O:19])=O.O1CCC[CH2:31]1>CN(C)C1C=CN=CC=1>[CH2:27]([CH:2]1[C:3]2=[N:5][C:6]3[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][CH:9]=[CH:8][C:7]=3[C:16]([OH:26])=[C:17]2[C:18](=[N:20][C:21]2[S:22][CH:23]=[CH:24][N:25]=2)[O:19]1)[CH2:28][CH2:29][CH3:31]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 134230832-[(2-chloro-1-oxo-pentyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide

Product 1

HCID 178442015HCID 178442015, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Using the procedure of Step B in Example 6, a mixture of 7 g of the product of Step B, 70 ml of tetrahydrofuran and 2.2 g of 4-dimethylamino-pyridine were reacted to obtain 6.1 g of 3-butyl-1,3-dihydro-1-[(2-thiazolyl)-imino]-5-trifluoromethyl-furo[3,4-b]quinoline-9-ol melting at 228° C. (decomposition).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2f66bc3138174480b7d2daee772596bf
Source dataset
uspto-grants-1984_12
Patent number
US04486438

Reaction notes

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