Sulfuric Acid → HCID 178443577, compound

A solution of octylmagnesium bromide was prepared by dropping 34.2 g (0.177 mol) of 1-bromoctane in 10 ml of diethyl ether into 6.5 g (0.268 mol) of magnesium in 10 ml of diethyl ether and refluxing for three hours. The solution of the Grignard reagent was transferred under nitrogen to the dropping funnel of a 150 ml three-necked flask additionally fitted with a reflux condenser, a magnetic stirrer and a nitrogen outlet and containing a solution of 15 g (0.118 mol) of N-ethyl-succinimide in 50 ml of absolute tetrahydrofuran. The Grignard reagent was added over a period of two hours. The reaction mixture with the precipitated alcoholate was allowed to stand at room temperature for two days. The suspension was poured into a mixture of ice and 10% H2SO4. After separation of the organic layer, the aqueous phase was extracted with diethyl ether (2 times). The combined organic phases were washed with saturated NaHCO3. After drying with anhydrous Na2SO4 and removing the solvent under reduced pressure, the residue was distilled with a Kugelrohr in vacuo to give 10 g of a yellow oil, 120° C. air bath temperature/0.9 mm Hg. A second fractionated distillation over a Vigreux column yielded 6.6 g pure product, b.p. 130° C./1.0 mm Hg.

1. temperaturerefluxing for three hours
2. customadditionally fitted with a reflux condenser, a magnetic stirrer and a nitrogen outlet
3. customAfter separation of the organic layer
4. extractionthe aqueous phase was extracted with diethyl ether (2 times)
5. washThe combined organic phases were washed with saturated NaHCO3
6. dry with materialAfter drying with anhydrous Na2SO4
7. customremoving the solvent under reduced pressure
8. distillationthe residue was distilled with a Kugelrohr in vacuo

ORD record

ord-43e581fca5d248d9a7009b16d9ce6a63

Source dataset

uspto-grants-1981_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04299840