反应详情

温度

140 °C

To 70 ml of dimethylformamide was added 2.2 g of 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehyde, followed by the addition of 2.5 g of cyanoacetylene. The mixture was heated under stirring at 140° C. for 15 hours and the solvent was then distilled off under reduced pressure. The residue was chromatographed on silica gel and eluted with chloroform and recrystallized from acetonitrile to give 0.83 g of 3-cyano-1-azaxanthone as crystals, m.p. 220°-226° C.

1. temperatureThe mixture was heated
2. distillationthe solvent was then distilled off under reduced pressure
3. customThe residue was chromatographed on silica gel
4. washeluted with chloroform
5. customrecrystallized from acetonitrile