反应详情

To sodium hydride (0.20 g) taken in dry THF (15 ml), N-methyl piperazine (0.93 ml) was added under nitrogen at 0° C. 2,3-Dibromopyrazine (2 g) taken in 15 ml dry THF was added to the above mixture at 0° C. The reaction mixture was allowed to reflux for overnight and quenched with water (5 ml). The organic layer was removed under vacuum. The resulting crude mass was purified by column chromatography to afford 2-bromo-5-(4-methylpiperazin-1-yl)pyrazine as pure product.

1. additionwas added to the above mixture at 0° C
2. temperatureto reflux for overnight
3. customquenched with water (5 ml)
4. customThe organic layer was removed under vacuum
5. customThe resulting crude mass was purified by column chromatography