反应详情

A mixture of N-benzyloxycarbonyl guanidine 2.52 g (13.1 mmol), diisopropylethylamine 1.81 ml (8.7 mmol), 1-bromo-2-butanone 0.89 ml (8.7 mmol) and ethyl acetate 50 ml was stirred at room temperature overnight. The reaction solution was washed with water and aqueous sodium chloride solution and dried on magnesium sulfate. After evaporation of the solvent, the residue was purified by a column chromatography on silica gel and further recrystallized from n-hexane to give 0.71 g of the title compound (yield: 33%).

1. washThe reaction solution was washed with water and aqueous sodium chloride solution
2. customdried on magnesium sulfate
3. customAfter evaporation of the solvent
4. customthe residue was purified by a column chromatography on silica gel
5. customfurther recrystallized from n-hexane