反应详情

4-Bromophenol (5 g, 28.9 mmol), 4-trifluoromethyl phenyl boronic acid (6.59 g, 34.7 mmol), potassium carbonate (12 g, 86.7 mmol) and palladium acetate (0.324 g, 1.445 mmol) are placed in water (50 mL), and the resulting mixture is stirred at room temperature over night under open air. The mixture is filtered through celite and extracted with ethyl acetate (3×200 ml). The combined organic layers are washed with water, 1N HCl, water, brine, dried (MgSO4), concentrated and chromatographed to yield the title compound as a white solid (6.0 g, 87%).

1. filtrationThe mixture is filtered through celite
2. extractionextracted with ethyl acetate (3×200 ml)
3. washThe combined organic layers are washed with water, 1N HCl, water, brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customchromatographed