Pyridine → HCID 86620600, compound

HRID 1161106Notes

Reaction equation

HRID 1161106 reaction equation
C(Cl)(=O)C(Cl)=O.[C:7]([C:10]1[CH:40]=[CH:39][C:13]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]([O:32][CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][O:34]3)[C:23]3[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=3)[C:26]([OH:28])=[O:27])=[CH:18][CH:17]=2)=[C:12]([CH3:41])[C:11]=1[OH:42])(=[O:9])[CH3:8].N1C=CC=CC=1.[NH2:49][NH:50][C:51]([NH2:53])=[S:52]>O1CCCC1.CN(C)C=O.CC(C)=O.O>[NH2:49][NH:50][C:51]([NH2:53])=[S:52].[C:7]([C:10]1[CH:40]=[CH:39][C:13]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]([O:32][CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][O:34]3)[C:23]3[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=3)[C:26]([OH:28])=[O:27])=[CH:18][CH:17]=2)=[C:12]([CH3:41])[C:11]=1[OH:42])(=[O:9])[CH3:8]

Participants

8

Reactant 4

HCID 1049PyridineHCID 65578Oxalyl chlorideHCID 2723789ThiosemicarbazideHCID 66699605HCID 66699605, compound

Product 1

HCID 86620600HCID 86620600, compound

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideCatalystHCID 8028TetrahydrofuranSolventHCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

Add oxalyl chloride (0.660 mg, 5.20 mmol) to a solution of 3-[[4-(4-acetyl-3-hydroxy-2-methyl-phenoxymethyl)-phenyl]-(tetrahydro-pyran-2-yloxy)-methyl]-benzoic acid, 1.00 g, 2.04 mmol) in tetrahydrofuran (0.20M). Add dimethylformamide (5 drops). Add pyridine (0.322 g, 4.08 mmol) and thiosemicarbazide (0.223 g, 2.45 mmol). Stir the reaction overnight. Evaporate solvents. Dissolve brown tar in acetone/water. Extract with CH2Cl2 (3×) and ethyl acetate (3×). Combine organic extracts, dry and concentrate to afford the title compound, which was used without further purification (1.20 g, 2.04 mmol, 99%): MS (m/z): 563 (M−H).

Workup

  1. customthe reaction overnight
  2. extractionExtract with CH2Cl2 (3×) and ethyl acetate (3×)
  3. customCombine organic extracts, dry
  4. concentrationconcentrate

Sources & evidence

ORD record
ord-552247ae256f4170b5d38a9cd305fe8e
Source dataset
uspto-grants-2010_10
Patent number
US07816523B2

Reaction notes

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