Pyrrole → 1-(6-Phenyl-2-pyrrol-1-yl-pyrimidin-4-yl)-piperidin-4-ol

HRID 1161670Notes

Reaction equation

HRID 1161670 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.Cl[C:7]1[N:12]=[C:11]([N:13]2[CH2:18][CH2:17][CH:16]([OH:19])[CH2:15][CH2:14]2)[CH:10]=[C:9]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:8]=1.[H-].[Na+]>CN(C=O)C>[C:20]1([C:9]2[N:8]=[C:7]([N:1]3[CH:5]=[CH:4][CH:3]=[CH:2]3)[N:12]=[C:11]([N:13]3[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]3)[CH:10]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 8027PyrroleHCID 24758Sodium hydrideHCID 586260781-(2-Chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol

Product 1

HCID 586261721-(6-Phenyl-2-pyrrol-1-yl-pyrimidin-4-yl)-piperidin-4-ol

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from pyrrole (0.072 g, 1.07 mmol) and compound 1-(2-chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol (0.31 g, 1.07 mmol) in the presence of 60% NaH (0.039 g, 1.6 mmol) in DMF by a procedure analogous to that disclosed in Example 93.

Sources & evidence

ORD record
ord-d5443daa33ff43a68cce8fb9686fceb6
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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