Triethylamine → HCID 17961828, compound

HRID 1161891Notes

Reaction equation

HRID 1161891 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH:12]1[C:20]#[N:21])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:29][NH:30][OH:31].Cl>CCO>[OH:31][N:30]([C:20](=[NH:21])[CH:12]1[CH2:13][C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]1[C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH3:29]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77906N-methylhydroxylamine hydrochlorideHCID 17961855HCID 17961855, compound

Product 1

HCID 17961828HCID 17961828, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Benzyloxycarbonyl-2-cyanoindoline was added to a solution of triethylamine (2 eq.) and MeNHOH.HCl (2 eq.) in EtOH. After stirring overnight the reaction mixture was evaporated, dissolved in EtOAc, washed with water, dried over Na2SO4 and evaporated to afford the title compound.

Workup

  1. customwas evaporated
  2. dissolutiondissolved in EtOAc
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. customevaporated

Sources & evidence

ORD record
ord-b3f1a868bb7f421aa38c158dad9eaa81
Source dataset
uspto-grants-2010_10
Patent number
US07820660B2

Reaction notes

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