Dimethylformamide → HCID 66893075, compound

HRID 1162073Notes

Reaction equation

HRID 1162073 reaction equation
C(Cl)(=O)C([Cl:4])=O.CN(C=O)C.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][C:15]=1[S:21]([C:24]1[CH:25]=[C:26]([CH2:33]O)[C:27]2[O:31][CH:30]=[CH:29][C:28]=2[CH:32]=1)(=[O:23])=[O:22]>C(Cl)Cl>[Cl:4][CH2:33][C:26]1[C:27]2[O:31][CH:30]=[CH:29][C:28]=2[CH:32]=[C:24]([S:21]([C:15]2[CH:16]=[C:17]([CH3:20])[CH:18]=[CH:19][C:14]=2[O:13][CH3:12])(=[O:23])=[O:22])[CH:25]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 66894542HCID 66894542, compound2×

Product 1

HCID 66893075HCID 66893075, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (0.1 mL, 1.1 mmol) was dissolved in dry DCM (2 mL) and DMF (0.9 mL, 1.1 mmol) was added (very exothermic reaction). {5-[(2-Methoxy-5-methylphenyl)sulfonyl]-1-benzofuran-7-yl}methanol (370 mg, 1.1 mmol; Intermediate 68)

Workup

  1. customvery exothermic reaction)

Sources & evidence

ORD record
ord-45b8089de67243c1a4f7ada2cb137fe1
Source dataset
uspto-grants-2010_10
Patent number
US07820675B2

Reaction notes

Loading…