Neopentyl alcohol → HCID 66995428, compound

HRID 1162404Notes

Reaction equation

HRID 1162404 reaction equation
[CH3:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[H-].[Na+].[Br:9][C:10]1[CH:11]=[CH:12][C:13](F)=[C:14]([CH:17]=1)[C:15]#[N:16]>CN(C=O)C>[Br:9][C:10]1[CH:11]=[CH:12][C:13]([O:4][CH2:3][C:2]([CH3:6])([CH3:5])[CH3:1])=[C:14]([CH:17]=1)[C:15]#[N:16]

Participants

5

Reactant 3

HCID 6404Neopentyl alcoholHCID 24758Sodium hydrideHCID 27249005-Bromo-2-fluorobenzonitrile

Product 1

HCID 66995428HCID 66995428, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 2,2-dimethyl-1-propanol and sodium hydride were stirred at 0° C. in DMF, 5-bromo-2-fluorobenzonitrile was added thereto, followed by reaction at room temperature to obtain 5-bromo-2-(2,2-dimethylpropoxy)benzonitrile. NMRC: 3.67 (2H, s), 6.83 (1H, d), 7.64 (1H, d).

Workup

  1. customfollowed by reaction at room temperature

Sources & evidence

ORD record
ord-ca9f360b351a423392dba70c6627b915
Source dataset
uspto-grants-2010_10
Patent number
US07820700B2

Reaction notes

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