Tetrahydrofuran → HCID 68647686, compound

HRID 1162577Notes

Reaction equation

HRID 1162577 reaction equation
C([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[N:11]=[C:12]([NH:15][CH2:16][C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)[S:13][CH:14]=1)(C)C.[H-].[Na+].Br[CH2:25][C:26]1[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=1[C:28]#[N:29].[CH2:34]1[CH2:38]OC[CH2:35]1>>[CH:34]([C:8]1[CH:9]=[CH:4][C:5]([C:10]2[N:11]=[C:12]([N:15]([CH2:25][C:26]3[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=3[C:28]#[N:29])[CH2:16][C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[S:13][CH:14]=2)=[CH:6][CH:7]=1)([CH3:38])[CH3:35]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 895992-(Bromomethyl)benzonitrileHCID 86601763HCID 86601763, compound

Product 1

HCID 68647686HCID 68647686, compound

Procedure

2-({[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-methyl)-benzonitrile was prepared by stirring (4-(-isopropyl-phenyl)-thiazol-2-yl)-thiophen-2-ylmethyl-amine (100 mg, 0.31 mmol), NaH (26 mg, 60%, 0.62 mmol), and 2-bromomethylbenzonitrile (72 mg, 0.372 mmol) in THF (50 mL) at room temperature. After 3 h, the reaction mixture was concentrated under high vacuum. The crude product used without purification.

Workup

  1. concentrationthe reaction mixture was concentrated under high vacuum
  2. customThe crude product used without purification

Sources & evidence

ORD record
ord-3cdb053126e74dafbfdf49cacd46aa23
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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