Triethylamine → HCID 67274031, compound

HRID 1163345Notes

Reaction equation

HRID 1163345 reaction equation
[CH:1]([N:14]1[CH2:17][CH:16]([NH2:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]1[CH:21]=[C:22]([N+:27]([O-:29])=[O:28])[CH:23]=[CH:24][C:25]=1F.C(N(CC)CC)C>C(OCC)(=O)C.O>[CH:1]([N:14]1[CH2:17][CH:16]([NH:18][C:25]2[CH:24]=[CH:23][C:22]([N+:27]([O-:29])=[O:28])=[CH:21][C:20]=2[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 57445463-Amino-1-(diphenylmethyl)azetidine

Product 1

HCID 67274031HCID 67274031, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 7.96 g of 1-benzhydrylazetidin-3-ylamine (33.41 mmol), 3.69 ml 3,4-difluoronitrobenzene (33.41 mmol) and 4.65 ml triethylamine (33.41 mmol)) in 50 ml ethyl acetate was stirred for 2 weeks at 60° C. The reaction was diluted with water and the product extracted with ethyl acetate. The organic layer was washed with water and brine, dried over MgSO4, filtered and evaporated.

Workup

  1. extractionthe product extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-b0f2d4c83f3b4410b0b6ecfd2e7d8b8e
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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