Diethylamine → HCID 68446679, compound

HRID 1163397Notes

Reaction equation

HRID 1163397 reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([NH:10][C:11](=[O:23])[C:12]3[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[C:15](F)=[CH:14][C:13]=3Cl)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH4+:24].[OH-].[CH2:26]([NH:28][CH2:29][CH3:30])[CH3:27]>O1CCOCC1>[NH2:24][C:15]1[C:16]([N+:18]([O-:20])=[O:19])=[CH:17][C:12]([C:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]3[N:3]=[CH:2][S:1][C:5]=3[CH:6]=2)=[O:23])=[C:13]([N:28]([CH2:29][CH3:30])[CH2:26][CH3:27])[CH:14]=1

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 14923Ammonium HydroxideHCID 68444790HCID 68444790, compound

Product 1

HCID 68446679HCID 68446679, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of the aforementioned amide (3 mmol) in dioxane was reacted with aqueous NH4OH and subsequently with diethylamine using the one-pot procedure described for Example 115 to yield 4-amino-N-benzothiazol-6-yl-2-diethylamino-5-nitrobenzamide as a yellow solid.

Sources & evidence

ORD record
ord-a92af592b00f42159c4f89afcceacf21
Source dataset
uspto-grants-2010_10
Patent number
US07820821B2

Reaction notes

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