反应详情

温度

65 °C

Benzylbromide (3 mmol) and K2CO3 (6 mmol) were added to a solution of 2-nitroimidazole (2 mmol) in DMF (6 mL). The mixture was stirred at 60-70° C. for 4 h or overnight. The contents were cooled to room temperature, and water (30 mL) was added. The mixture was extracted with EtOAc (3×15 mL). The combined extracts were dried over MgSO4, filtered, and the solvent was removed in vacuo to afford 1-benzyl-2-nitro-1H-imidazole. The product used for further transformation without further purification.

1. temperatureThe contents were cooled to room temperature
2. extractionThe mixture was extracted with EtOAc (3×15 mL)
3. dry with materialThe combined extracts were dried over MgSO4
4. filtrationfiltered
5. customthe solvent was removed in vacuo