Diethyl (ethoxymethylene)malonate → HCID 54315930, compound

HRID 1163860Notes

Reaction equation

HRID 1163860 reaction equation
CO[C:3]1[CH2:7][CH2:6][CH2:5][N:4]=1.C(OC(=O)[C:12](=[CH:18]OCC)[C:13]([O:15]CC)=O)C.[C:23]([O-])(=O)[CH3:24].[NH4+:27]>>[CH2:23]([C:18]1[N:27]=[C:3]2[CH2:7][CH2:6][CH2:5][N:4]2[C:13](=[O:15])[CH:12]=1)[CH3:24]

Participants

4

Reactant 3

HCID 6871Diethyl (ethoxymethylene)malonateHCID 3534432-Methoxy-1-PyrrolineHCID 517165Ammonium Acetate

Product 1

HCID 54315930HCID 54315930, compoundYield 7.1%

Procedure

According to HU-Patent Specification No. 167 676 2-methoxy-1-pyrroline is heated with diethyl-ethoxymethylene-malonate for 8 hours in the presence of ammonium acetate and the reaction mixture is processed in a complicated manner to give ethyl 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine with a yield of 7.1%. No melting point of the product is given, the product is characterized only by IR and PMR spectra.

Sources & evidence

ORD record
ord-9e324a26c9254c95b33828ac5f9a3824
Source dataset
uspto-grants-1983_01
Patent number
US04367229

Reaction notes

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