Potassium Carbonate → Phenol, 4-(4-((3,4,5-trimethoxyphenyl)methyl)-1-piperazinyl)-, monohydrochloride

HRID 1164489Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][Cl:7].[OH:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>>[ClH:7].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][N:25]1[CH2:24][CH2:23][N:22]([C:19]2[CH:18]=[CH:17][C:16]([OH:15])=[CH:21][CH:20]=2)[CH2:27][CH2:26]1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

HCID 92467p-(1-Piperazinyl)phenol

Product 1

HCID 3062140Phenol, 4-(4-((3,4,5-trimethoxyphenyl)methyl)-1-piperazinyl)-, monohydrochlorideYield 54.2%

Procedure

8.3 g of 3,4,5-trimethoxybenzyl chloride and 3.5 g of N-(4-hydroxyphenyl)-piperazine and 3.5 g of K2CO3 are reacted and processed according to example 2. 4.2 g of N-(3,4,5-trimethoxy-benzyl)-N'-(4-hydroxyphenyl)-piperazine hydrochloride is obtained. Mp.: 268° C. (decomposition).

Sources & evidence

ORD record: ord-5e4ce0fa57ac4c5cb8a6f3749a74713d
Source dataset: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04370330

Reaction notes

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