4-Chlorobenzyl alcohol → HCID 14072267, compound

HRID 1165429Notes

Reaction equation

HRID 1165429 reaction equation
[Cl:1][C:2]1[C:3](=[O:19])[N:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1Cl.[Cl:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][OH:26])=[CH:23][CH:22]=1.[OH-].[K+]>CN(C)C=O>[Cl:1][C:2]1[C:3](=[O:19])[N:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1[O:26][CH2:25][C:24]1[CH:27]=[CH:28][C:21]([Cl:20])=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 133974-Chlorobenzyl alcoholHCID 14797Potassium HydroxideHCID 27740364,5-Dichloro-2-[4-(trifluoromethyl)phenyl]pyridazin-3(2H)-one

Product 1

HCID 14072267HCID 14072267, compoundYield 72.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 50 ml of N,N-dimethylformamide were dissolved 2.0 g (6.5 m mol) of 4,5-dichloro-2-(4-trifluoromethylphenyl)-3(2H)-pyridazinone and 0.92 g (6.5 m mol) of p-chlorobenzyl alcohol, and thereto was added 0.51 g of powdery potassium hydroxide. Then, the procedures in Synthesis Example 2 were repeated to give 1.94 g of the intended compound.

Workup

  1. customThen, the procedures in Synthesis Example 2

Sources & evidence

ORD record
ord-0c6b556538d1453b835f1cee6966849a
Source dataset
uspto-grants-1990_03
Patent number
US04910201

Reaction notes

Loading…