4-Chlorobenzyl alcohol → HCID 14072382, compound

HRID 1165431Notes

Reaction equation

HRID 1165431 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:13](=[O:14])[C:12]([Cl:15])=[C:11](Cl)[CH:10]=[N:9]2)=[N:6][CH:7]=1.[Cl:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][OH:23])=[CH:20][CH:19]=1.[OH-].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:13](=[O:14])[C:12]([Cl:15])=[C:11]([O:23][CH2:22][C:21]3[CH:24]=[CH:25][C:18]([Cl:17])=[CH:19][CH:20]=3)[CH:10]=[N:9]2)=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 133974-Chlorobenzyl alcoholHCID 14797Potassium HydroxideHCID 198618124,5-Dichloro-2-(5-chloropyridin-2-yl)pyridazin-3(2H)-one

Product 1

HCID 14072382HCID 14072382, compoundYield 25.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 30 ml of N,N-dimethylformamide were dissolved 1.5 g (5.1 m mol) of 2-(5-chloropyridine-2-yl)-4,5-dichloropyridazinone and 0.73 g (5.1 m mol) of p-chlorobenzyl alcohol, and thereto was added 0.34 g of powdery potassium hydroxide. Then, the procedures in Synthesis Example 2 were repeated to give 500 mg of the intended compound.

Workup

  1. customThen, the procedures in Synthesis Example 2

Sources & evidence

ORD record
ord-31fa828a93b845c6902c96462d505b4d
Source dataset
uspto-grants-1990_03
Patent number
US04910201

Reaction notes

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