Hydrochloric Acid → HCID 69842499, compound

HRID 1169063Notes

Reaction equation

HRID 1169063 reaction equation
[CH2:1]([O:3][C:4](=[O:42])[CH2:5][NH:6][C:7]([C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([NH:17][CH2:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH:24]([O:27][CH:28]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[CH2:23][CH2:22]3)=[N:13][N:12]2[CH:41]=1)=[O:8])[CH3:2].[ClH:43]>O1CCCC1.C(OCC)(=O)C>[ClH:43].[ClH:43].[CH2:1]([O:3][C:4](=[O:42])[CH2:5][NH:6][C:7]([C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([NH:17][CH2:18][CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][CH:24]([O:27][CH:28]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)[C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:25][CH2:26]3)=[N:13][N:12]2[CH:41]=1)=[O:8])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22989383N-[6-[3-[4-(diphenylmethoxy)piperidino] propylamino]imidazo[1,2-b]pyridazine-2-carbonyl]glycine ethyl ester

Product 1

HCID 69842499HCID 69842499, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

0.628 g of N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino]imidazo[1,2-b]pyridazine-2-carbonyl]glycine ethyl ester was dissolved in 10 ml of tetrahydrofuran; 1.5 ml of a 4 N hydrogen chloride solution in ethyl acetate was added, followed by concentration under reduced pressure. To the residue, 10 ml of methanol was added, followed by concentration under reduced pressure. The crystal obtained was collected and washed with ethyl acetate to yield 0.658 g of the title compound.

Workup

  1. concentrationfollowed by concentration under reduced pressure
  2. additionTo the residue, 10 ml of methanol was added
  3. concentrationfollowed by concentration under reduced pressure
  4. customThe crystal obtained
  5. customwas collected
  6. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-cdcad52efd3d41448f3271d6a41b6f41
Source dataset
uspto-grants-2003_09
Patent number
US06627630B1

Reaction notes

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