反应详情

To N-(4-piperidinyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxamide (0.15 g) and tetrahydro-4H-pyran-4-one (0.06 g) dissolved in 1,2-dichloroethane (7 ml) was added under ice cooling sodium triacetoxyborohydride (0.13 g), and the resulting mixture was stirred at room temperature overnight under a nitrogen atmosphere. The reaction mixture was neutralized with a 1 N aqueous solution of sodium hydroxide, was then concentrated and was extracted with ethyl acetate. The organic layer was washed with water and an aqueous saturated solution of sodium chloride, and was then dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain crude crystals. The crude crystals were recrystallized from ethyl acetate/hexane to obtain N-(1-(tetrahydropyran-4-yl)piperidin-4-yl)-7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxamide (compound 56) (0.13 g) as colorless prisms.

1. additionwas added under ice
2. concentrationwas then concentrated
3. extractionwas extracted with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialan aqueous saturated solution of sodium chloride, and was then dried with anhydrous magnesium sulfate
6. customThe resulting organic layer was evaporated under reduced pressure
7. customto remove the solvent
8. customto obtain crude crystals
9. customThe crude crystals were recrystallized from ethyl acetate/hexane