反应详情

温度

90 °C

A mixture of 4-hydroxybenzyl alcohol (3.00 g), 2-bromoethyl propyl ether (4.0 ml), sodium iodide (4.75 g), potassium carbonate (6.68 g) and DMF (30 ml) was stirred at 90° C. for 3 days. The reaction mixture was mixed with water, and was extracted with ethyl acetate. The organic layer was washed with water and an aqueous saturated solution of sodium chloride, and was dried with magnesium sulfate. After concentration under reduced pressure, the residue was subjected to separation and purification using column chromatography (ethyl acetate:hexane 1:2→1:1) to obtain 4-(2-propoxyethoxy)benzyl alcohol (2.27 g) as a light yellow, oily substance.

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialan aqueous saturated solution of sodium chloride, and was dried with magnesium sulfate
4. concentrationAfter concentration under reduced pressure
5. customthe residue was subjected to separation and purification