反应详情

To a solution of the compound obtained from step c in tetrahydrofuran (1.0 eq), was added and lithium hydroxide (5.0 eq) in water (as 5N solution). The mixture was stirred at room temperature over night. The solvent was removed under reduced pressure and the residue thus obtained was diluted with water and acidified with drops of concentrated hydrochloric acid. The organic compound was extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulphate and finally concentrated under reduced pressure to afford title organic compound.

1. customThe solvent was removed under reduced pressure
2. customthe residue thus obtained
3. extractionThe organic compound was extracted with ethyl acetate
4. washwashed with brine
5. dry with materialdried over anhydrous sodium sulphate
6. concentrationfinally concentrated under reduced pressure
7. customto afford title organic compound